Pair Name	Narciclasine, Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Target-->STAT3
Gene Regulation	Down-regulation	Phosphorylation	STAT3	hsa6774
	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	Our findings successfully highlight the STAT3 as the direct therapeutic target of Nar in ER-positive breast cancer cells, especially, Nar leaded STAT3 degradation as a promising strategy for the tamoxifen-resistant breast cancer treatment.